Unsupervised gene expression analyses identify IPF-severity correlated signatures, associated genes and biomarkers

Abstract Background Idiopathic Pulmonary Fly Fishing Wallets Fibrosis (IPF) is a fatal fibrotic lung disease occurring predominantly in middle-aged and older adults.The traditional diagnostic classification of IPF is based on clinical, radiological, and histopathological features.However, the considerable heterogeneity in IPF presentation suggests

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Novel mitochondria-targeted heat-soluble proteins identified in the anhydrobiotic Tardigrade improve osmotic tolerance of human cells.

Tardigrades are able to tolerate almost complete dehydration through transition to a metabolically inactive state, called "anhydrobiosis".Late Embryogenesis Abundant (LEA) proteins are heat-soluble proteins involved in the desiccation tolerance of many anhydrobiotic organisms.Tardigrades, Ramazzottius varieornatus, however, express predominantly ta

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Transcriptome analysis reveals genes commonly induced by Botrytis cinerea infection, cold, drought and oxidative stresses in Arabidopsis.

Signaling pathways controlling biotic and abiotic stress responses may interact synergistically or antagonistically.To identify the similarities and differences among responses to diverse stresses, we analyzed previously published microarray data on the transcriptomic responses of Arabidopsis to infection with Botrytis cinerea (a biotic stress), an

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